It should dissipate by early next week, the hurricane center said.
The "cone of error" in the forecast track only predicts where the storm's center might go, and even on its edges, winds can push a powerful storm surge into shore dozens of miles from where Florence's eyewall strikes land.
Although Florence was downgraded from Category 4 status, it is still considered an extremely unsafe storm with maximum sustained winds near 125 miles per hour.
Federal states of emergency have been declared in all three states, and collectively about 1.5 million people have fled the coast under mandatory evacuation orders.
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Tropical weather heated up across the Atlantic Wednesday, prompting alerts throughout the region, from the U.S. East Coast to the Caribbean's Lower Antilles, as two active hurricanes, two named storms and two potential storms brewed. "This storm is extremely risky".
This storm is lined up behind Florence in the Atlantic.
Winds of tropical storm strength could reach Puerto Rico on Friday morning.
The cloud system associated with Isaac remains poorly organized and Saint Lucia fell between the rain bands of Isaac, hence the island has thus far not received the expected rainfall.
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Mr Bowles said winds would top 80mph in parts of the United Kingdom with heavy, fast moving rain.
Tornadoes: Tornadoes will be possible along and to the right of the track of Florence, including the Midlands, Pee Dee and Catawba Regions, this is especially in SC.
The Miami-based National Hurricane Centre (NHC) in its latest bulletin said that hurricane watches had gone into effect for Dominica, Martinique, and Guadeloupe, while a tropical storm watch is in effect for Antigua and Barbuda and Montserrat. Earlier forecasts showed that the storm was slated to directly hit around North and SC.
Isaac is moving west at 21 miles per hour. Regardless of development, heavy rainfall and gusty winds are expected across portions of northeastern Mexico, Texas, and Louisiana late this week.
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